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A daily healthspan foundation for every life stage●Pharmacist formulated · cGMP, FDA-registered facility●Five food-grade ingredients · One connected system●
Quelle365

The science

Aging is a network.

Energy production, inflammatory signaling, immune balance, oxidative balance, and tissue repair don’t age in isolation. Each influences the others, which is why support for one system alone may be incomplete.

Aging is a network

Connected systems, changing together.

Changes in one system ripple into others. Lower cellular energy affects repair; persistent inflammatory signaling affects energy, cognition, and tissue maintenance.

PuppyYoung adultMatureSeniorCellular energyMitochondrial healthInflammatory balanceImmune signalingBrain & nerve healthOxidative balanceTissue repair

A lifetime process

Four stages. One network.

Puppy

Build the foundation.

Growth is one of the most biologically demanding periods of life. Supporting cellular energy, membrane health, immune balance, and resilience early helps build the foundation for the years ahead.

Support the foundation

Systems that matter most

  • Rapid growth
  • Immune development
  • Neurological development
  • Mitochondrial development
  • Oxidative demands
  • Resilience

Why daily support may matter

Fast-growing tissue and a developing brain place high demands on cellular energy and membranes.

How Quelle365 fits

DHA supports developing brain-cell membranes, while astaxanthin and quercetin support oxidative balance during growth.

Different stage. Same network. Different priorities.

López-Otín et al., Cell, 2023

The 12 Hallmarks of Aging.

Select any Hallmark on the wheel or from the list to see the plain-English explanation, related ingredients, proposed connection, and evidence category.

Explore by life stage

The 12 Hallmarks of Aging arranged in a wheel around the four canine life stages: puppy, young adult, mature, and senior.
Tap any segment of the wheel, or pick a life stage to see how priorities shift. Hallmarks are active across the lifespan, but their relative importance and cumulative effects change as dogs age.

Hallmark 11 of 12

Chronic inflammation

Scientific category: Integrative · whole-body effects

“Inflammaging”: low-grade inflammatory signaling that can build from middle age and later show up as stiffness, itchy skin, or cloudy thinking.

Related Quelle365 ingredients

  • Ultramicronized PEA
  • Beta-caryophyllene
  • Quercetin
  • Astaxanthin
  • DHA

Proposed biological connection

All five ingredients are connected here: PEA and BCP support calm tissue signaling, quercetin and astaxanthin support balance during flare-ups, and DHA supports the body’s own resolution biology.

Evidence category

  • Canine evidence
  • Animal model
  • Cellular / mechanistic

Life-stage emphasis

Mature · Senior · Most relevant as aging progresses

Ingredient links reflect published research on the individual ingredients. The finished Quelle365™ formula has not itself been clinically tested against each Hallmark of Aging.

The longevity network

Research pathways behind the formula.

These are research pathways associated with individual ingredients in published studies, not clinical outcomes of the finished product.

  • SIRT1

    Master switch for cellular maintenance

    Studied with: Quercetin, Beta-caryophyllene

  • AMPK

    Cellular fuel sensor

    Studied with: Astaxanthin, PEA

  • PGC-1α

    Builds new mitochondria

    Studied with: Astaxanthin, Quercetin

  • Nrf2

    Antioxidant defense switch

    Studied with: Astaxanthin

  • FOXO3

    Longevity-associated gene

    Studied with: Astaxanthin

  • NF-κB

    Inflammatory signaling hub

    Studied with: PEA, Beta-caryophyllene

  • PPAR-α

    Lipid & inflammatory regulation

    Studied with: PEA

  • SPMs

    Specialized pro-resolving mediators

    Studied with: DHA

The eCSEPTIONOL® Formula

The five ingredients.

  • PEA

    Ultramicronized PEA

    Palmitoylethanolamide

    Supports healthy inflammatory and neuroimmune signaling

    A fatty-acid amide the body already makes to help calm irritated tissue. Ultramicronized PEA has been studied in dogs for skin and joint comfort, and in models of brain aging.

    • PPAR-α
    • AMPK
    • Mast-cell & microglial signaling
  • BCP

    Beta-caryophyllene

    From cloves & rosemary

    Supports cellular signaling and inflammatory balance

    A food-grade, non-psychoactive plant compound that engages the CB2 receptor. Research models link it to SIRT1 signaling and stress-response genes.

    • CB2
    • SIRT1
    • Stress-response genes
  • DHA

    DHA

    Omega-3 fatty acid

    Supports brain-cell membranes and healthy resolution biology

    A structural fat in brain and retina cell membranes, and the precursor to specialized pro-resolving mediators (SPMs) that help the body resolve inflammation.

    • SPMs
    • Membrane fluidity
    • Telomere–mitochondria axis
  • ASX

    Astaxanthin

    From microalgae

    Supports oxidative balance and mitochondrial resilience

    The carotenoid that gives salmon its color. A 2024 NIA Interventions Testing Program study reported extended median lifespan in male mice.

    • Nrf2
    • AMPK / FOXO3 / Klotho
    • PGC-1α
  • QUE

    Quercetin

    From apples & onions

    Supports cellular stress responses and energy-signaling pathways

    A dietary flavonoid studied for mitochondrial biogenesis in neuronal cells and as a senolytic compound in cell models.

    • NAD / SIRT1
    • PGC-1α
    • Senescence pathways

Evidence levels

Not all evidence is equal.

We label every connection so you can judge it for yourself. Ordered from most to least directly applicable to dogs.

  1. Canine evidenceStudied in dogs
  2. Human evidenceStudied in people
  3. Animal modelStudied in laboratory animals
  4. Cellular / mechanisticStudied in cells or pathways
  5. Network-level rationaleInferred from connected pathways

References

Peer-reviewed literature.

Hallmarks framework

PEA

  • Scuderi C, Golini L. Successful and Unsuccessful Brain Aging in Pets… Palmitoylethanolamide Nutritional Intervention. Animals. 2021;11(9):2584. doi.org/10.3390/ani11092584
  • Bellanti F, et al. Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission. Front Aging Neurosci. 2022;14:890855. doi.org/10.3389/fnagi.2022.890855

Beta-caryophyllene

  • Pant A, et al. Beta-caryophyllene modulates expression of stress response genes and mediates longevity in Caenorhabditis elegans. Exp Gerontol. 2014;57:81–95. doi.org/10.1016/j.exger.2014.05.007
  • Ricardi C, et al. Multi-target Protective Effects of β-caryophyllene at the Intersection of Neuroinflammation and Neurodegeneration. Int J Mol Sci. 2025;26(13):6027. doi.org/10.3390/ijms26136027

DHA

  • Wu S, et al. Lifelong docosahexaenoic acid intervention ameliorates aging in the telomere-DNA-mitochondria axis in telomerase-deficient mice. J Nutr Biochem. 2023;112:109202. doi.org/10.1016/j.jnutbio.2022.109202

Astaxanthin

  • Harrison DE, et al. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice. GeroScience. 2024;46(1):795–816. doi.org/10.1007/s11357-023-01011-0
  • Sorrenti V, et al. Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. Marine Drugs. 2020;18(7):351. doi.org/10.3390/md18070351

Quercetin

  • Ho CL, et al. Quercetin Increases Mitochondrial Biogenesis and Reduces Free Radicals in Neuronal SH-SY5Y Cells. Nutrients. 2022;14(16):3310. doi.org/10.3390/nu14163310
  • Zoico E, et al. Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence. Sci Rep. 2021;11(1):23237. doi.org/10.1038/s41598-021-02544-0

Cognition & inflammatory biology

  • Ponce J, et al. Role of specialized pro-resolving mediators in reducing neuroinflammation in neurodegenerative disorders. Front Aging Neurosci. 2022;14:780811. doi.org/10.3389/fnagi.2022.780811
  • Franck M, et al. Inflamm-aging as a diverse and context-dependent process. Ageing Res Rev. 2025:102880. doi.org/10.1016/j.arr.2025.102880